arq-ARQ 531_蛋白酪氨酸激酶-MedChemExpress LLC

联系我们时请说明是91化工仪器网上看到的信息，谢谢!

产品简介 品牌 MedChemExpress (MCE) 货号 HY-112215 规格 10 mM * 1 mL；5 mg；10 mg 供货周期 现货 应用领域 生物产业     ARQ 531 是 BTK 可逆的非共价抑制剂，其对 WT-BTK 和 C481S-BTK 的 IC50 值分别为 0.85 nM 和 0.39 nM。
详细介绍 ARQ 531

产品活性：ARQ 531 是 BTK 可逆的非共价抑制剂，其对 WT-BTK 和 C481S-BTK 的 IC50 值分别为 0.85 nM 和 0.39 nM。

研究领域：Protein Tyrosine Kinase/RTK

作用靶点：Btk

In Vitro: ARQ 531 shows strong target inhibition in TMD8 cell line. The IC50 values are 0.85 nM and 0.39 nM for WT-BTK and C481S-BTK, respectively, in biochemical assay. Additionally, ARQ 531 also shows strong inhibition of TEK kinases with IC50s of 5.23 nM (BMX), 5.80 nM (TEC), 36.4 nM (TXK). The IC50s of ARQ 531 for SRC kinases are 3.86 nM (LCK), 4.22 nM (YES), 9.71 nM (BLK), 18.3 nM (HCK), 18.8 nM (LYNa), 25.9 nM (FGR), 32.2 nM (FYN), 48.0 nM (FRK) and for TRK kinases are 11.7 nM (TrkB), 13.1 nM (TrkA), 19.1 nM (TrkC). ARQ 531 inhibits proliferation of diverse types of cell lines (TMD8: GI50=1.7 nM, REC1: GI50=0.55 nM) and shows potency in cell lines that are addict to BCR, Src-family kinase and PI3K/AKT pathways.

In Vivo: ARQ 531 is efficacious in TMD-8 tumor xenograft model. ARQ 531 causes complete tumor regression after 14 days of treatment. ARQ 531 is also efficacious in collagen induced arthritis model. ARQ 531 demonstrates potent efficacy against arthritis in mouse model. In the BTK driven TMD8 xenograft mouse model, ARQ 531 demonstrates excellent anti-tumor activity with durable response. ARQ 531 demonstrates in vivo efficacy in a mouse collagen-induced arthritis (CIA) model.

相关产品：Kinase Inhibitor Library | Covalent Screening Library | Clinical Compound Library | Clinical Compound Library Plus | Protein Tyrosine Kinase Compound Library | Anti-Cancer Compound Library | Bioactive Compound Library Plus | Ibrutinib | Acalabrutinib | Fenebrutinib | Evobrutinib | Ibrutinib-biotin | Tirabrutinib | ( )-Zanubrutinib | Spebrutinib | GDC-0834 | Vecabrutinib | BMX-IN-1 | BTK IN-1 | CGI-1746 | RN486 | PRN1008 | BMS-986195 | CNX-774 | PCI-33380 | QL47 | BMS-986142 | BMS-935177 | LFM-A13 | CG-806 | Btk inhibitor 2 | PCI 29732

以上信息由企业自行提供，信息内容的真实性、准确性和合法性由相关企业负责，91化工仪器网对此不承担任何保证责任。
温馨提示：为规避购买风险，建议您在购买产品前务必确认供应商资质及产品质量。 搜本商铺 或 搜全站

MedChemExpress LLC - 主营产品： 西罗莫司 Rapamycin,瑞沙托维 TAK-242,奥拉帕尼 Olaparib

地址：上海市浦东新区张衡路1999弄3号楼      联系电话：86-021-58955995      手机：18019480960     传真：86-021-53700325
91化工仪器网 设计制作，未经允许翻录必究 .      Copyright(C) http://www.chem17.com,      All rights reserved. 以上信息由企业自行提供，信息内容的真实性、准确性和合法性由相关企业负责，91化工仪器网对此不承担任何保证责任。
温馨提示：为规避购买风险，建议您在购买产品前务必确认供应商资质及产品质量。
会员登录