Mycifradin 硫酸新霉素 Neomycin sulfate-91化工仪器网

价格：面议

生产地：品牌：MedChemExpress （MCE）

移动电话：18019480960公司传真：86-021-53700325

更新时间：2019-06-26

MedChemExpress (MCE) 专注于为全球科学家提供高品质的生物活性小分子化合物，化合物库及各类试剂盒，总部位于美国新泽西。
 MedChemExpress (MCE) 产品作用于 20 多个热门信号通路及研究领域的300多个细分靶点，拥有 10000 特异性抑制剂、激动剂，以及 30 活性化合物筛选库；
 我们坚持对所有产品进行严格质检，确保产品的高品质和高纯度；
 MedChemExpress (MCE) 产品已被全球数万名科学家信赖，并被大量Top文献和Patent引用；
 我们拥有专业的技术团队追踪全球前沿科技进展，不断丰富各个靶点的特异性产品，坚持做 您身边的抑制剂大师 ；
 MedChemExpress (MCE) 与全球众多知名药企和科研机构保持深度合作；
 大量产品有中国库存，工作日 16:00 前订单确保当日发货，次日送达。
MCE 中国：www.MedChemExpress.cn

Hotline: 400-820-3792
Tel: 021-58955995
Email: sales@MedChemExpress.cn
Tech Support: 021-58950656

产品活性：Neomycin sulfate是用于预防或治疗 细菌 感染的氨基糖苷类抗生素。

研究领域：Anti-infection | Membrane Transporter/Ion Channel

作用靶点：Bacterial | Calcium Channel

In Vitro: Neomycin inhibits thrombin-stimulated release of inositol 1,4,5-trisphosphate (IP3), by selectively binding PIP2, but does not inhibit 32P incorporation into PI or initiation of DNA synthesis. Neomycin (10 μM-1 mM) induces considerable release of [3H]arachidonic acid from phosphatidylinositol, phosphatidylcholine and phosphatidylethanolamine in saponin-permeabilized human platelets prelabeled with [3H]arachidonic acid. Moreover, neomycin enhances arachidonic acid release induced by thrombin. Addition of neomycin (100 μM) to 45Ca2+-preloaded platelets elicits 45Ca2+ mobilizatioin from intracellular stores. Neomycin (0-10 mM) inhibits guanosine 5'-[gamma-thio]triphosphate-stimulated PLD activity in digitonin-permeabilized NG108-15 cells in a concentration-dependent manner (50% inhibition at 100 μM). Neomycin similarly inhibits PLD activity present in rat brain membranes and assayed in vitro with [3H]phosphatidylcholine as substrate (50% inhibition at 65 μM). Neomycin (5 mM) causes reversible reductions in the level of intracellular Ca2+, but PtdIns(4,5)P2 is not required for the channel activity.

相关产品：FDA-Approved Drug Library Plus | Drug Repurposing Compound Library | Anti-Infection Compound Library | FDA-Approved Drug Library Mini | Covalent Screening Library | FDA-Approved Drug Library | Drug Repurposing Compound Library Plus | Bioactive Compound Library Plus | Membrane Transporter/Ion Channel Compound Library | Puromycin Dihydrochloride | Tunicamycin | G-418 disulfate | Hygromycin B | Bleomycin sulfate | Vancomycin hydrochloride | Ampicillin sodium | Salinomycin | Avibactam sodium | Verapamil hydrochloride | Vaborbactam | Rifampicin | Minocycline hydrochloride | Nifedipine | Bedaquiline | Carbenicillin disodium | Ciprofloxacin | Gentamicin sulfate | Metronidazole | Ionomycin | Kanamycin sulfate | Methicillin sodium salt | Eravacycline dihydrochloride | Ceftazidime | Berberine chloride hydrate | Rimonabant Hydrochloride | Thapsigargin | Omadacycline hydrochloride | Chloramphenicol