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产品简介 品牌 MedChemExpress (MCE) 货号 HY-12359 规格 10 mM * 1 mL；1 mg； 供货周期 现货 应用领域 生物产业 TPPB是苯并内酰胺衍生的可渗透细胞的蛋白激酶C （PKC） 活化物，Ki 值为11.9 nM。
详细介绍 TPPB
产品活性：TPPB是苯并内酰胺衍生的可渗透细胞的蛋白激酶C (PKC) 活化物，Ki 值为11.9 nM。
研究领域：Epigenetics | TGF-beta/Smad
作用靶点：PKC
In Vitro: By use of a cell line derived from an Alzheimer’s disease patient, significant enhancement of sAPPα secretion is achieved at 1 μM concentration for TPPB (Compound 5e). TPPB has a role against Aβ25-35-induced neurotoxicity in PC12 cells. TPPB at concentration of 1 μM could antagonize Aβ25-35 induced cell damage. TPPB could increase the phosphorylation of Akt, PKC, MARCKS and MAPK, which are inhibited by Aβ25-35 treatment. TPPB inhibits the activation of caspase-3 induced by Aβ25-35.
In Vivo: TPPB is evaluated for induction of hyperplasia after topical application to the shaved backs of outbred Sencar mice and shows a modest response at 300 μg.
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