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产品简介 品牌 MedChemExpress (MCE) 货号 HY-17427 规格 10 mM * 1 mL；50 mg；100 mg 供货周期 现货 应用领域 生物产业 Emtricitabine is a nucleoside reverse transcriptase inhibitor （NRTI） with an EC50 of 0.01 #181;M in PBMC cell. It is an antiviral drug for the treatment of HIV infection.
详细介绍 Emtricitabine
产品活性：Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) with an EC50 of 0.01 M in PBMC cell. It is an antiviral drug for the treatment of HIV infection.
研究领域：Anti-infection
作用靶点：HIV | Reverse Transcriptase
In Vitro: Emtricitabine has in vitro activity against both laboratory strains of HIV-1 and HIV-2 and clinical isolates of HIV-1. The 50% effective concentration (EC50) ranges from 0.002 to 1.5 mol/L, depending on the viral isolate and cell line used. Emtricitabine demonstrates in vitro synergy with zidovudine and stavudine and additive in vitro activity when combines with zalcitabine or didanosine.
In Vivo: Reproductive and developmental toxicology studies are conducted with emtricitabine. Oral doses up to 1000 mg/kg/day provided daily area under the curve (AUC0 24) exposure to pregnant animals approximately 60- (mice) to 120-fold (rabbits) higher than that in humans at the recommended dose of 200 mg given once per day. In a mouse fertility study, emtricitabine had no effect on fertility, sperm count, or early embryonic development. There is no increased incidence of malformations in mouse and rabbit embryofetal toxicology studies. The development and fertility of F1 progeny are unaffected by emtricitabine in a mouse pre- and post-natal study. These data demonstrate a favorable pre-clinical reproductive safety profile for emtricitabine.
相关产品：FDA-Approved Drug Library Plus | Drug Repurposing Compound Library | Anti-Infection Compound Library | FDA-Approved Drug Library Mini | Anti-Virus Compound Library | CNS-Penetrant Compound Library | FDA-Approved Drug Library | Drug Repurposing Compound Library Plus | Bioactive Compound Library Plus | Dolutegravir | Maraviroc | Cenicriviroc | Ritonavir | Ebselen | Bictegravir | Tenofovir Disoproxil Fumarate | Lamivudine | Efavirenz | Atazanavir sulfate | Raltegravir potassium salt | Tipranavir | Triciribine | Mavorixafor trihydrochloride | Elvitegravir | Saquinavir | Betulinic acid | Zidovudine | Delavirdine mesylate | Miltefosine | Nelfinavir Mesylate | TAK-779 | Lopinavir | Abacavir | Cabotegravir | Etravirine | Nevirapine | Stavudine
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