Estradiol-Agofollin_天然产物-MedChemExpress LLC

联系我们时请说明是91化工仪器网上看到的信息，谢谢!

详细介绍 Estradiol

产品活性：Estradiol 是一种类固醇性激素，对维持女性的生育能力和第二性征至关重要。

研究领域：Others | metabolic Enzyme/Protease

作用靶点：Estrogen Receptor/ERR | Endogenous metabolite

In Vitro: Estradiol causes new dendritic spines and synapses in hippocampal CA1 pyramidal cells. Estradiol increases NMDA receptor binding by 46% in parallel with dendritic spine and synapse density. Estradiol also elevates sensitivity of CA1 pyramidal cells to NMDA receptor-mediated synaptic input and such an effect is correlated with the estradiol-induced increase in dendritic spine density in the apical dendritic tree of these cells. Estradiol reduces Ba2+ entry reversibly via Ca2+ channels in acutely dissociated and cultured neostriatal neurons. Estradiol also reduces Ba2+ currents but is significantly less effective than Estradiol in rat neostriatal neurons. Estradiol dose-dependently inhibits IL-1-, TNF-, and IL-1 and TNF-induced production of bioassayable IL-6. Estradiol blocks TNF-induced IL-6 production and osteoclast development in primary bone cell cultures derived from neonatal murine calvaria.

In Vivo: Estradiol functions in hippocampal synapse density during the estrous cycle in the adult rat. Estradiol reverses the ovariectomy-induced decrease in spine density. Estradiol in combination with progesterone enhances spine density for 2 to 6 h but decreases following estradiol alone.

相关产品：Human Endogenous metabolite Compound Library | FDA-Approved Drug Library Mini | Natural Product Library | FDA-Approved Drug Library | metabolism/Protease Compound Library | Bioactive Compound Library Plus | 3-Methyladenine | Tamoxifen | Hydrocortisone | Fulvestrant | Acetylcysteine | Retinoic acid | Calcitriol | Melatonin | Prostaglandin E2 | ATP | Nicotinamide | 4-Hydroxytamoxifen | Acetaminophen | Prostaglandin E1 | DHEA | Corticosterone | Elacestrant dihydrochloride | Docosahexaenoic Acid | Progesterone | Heparan Sulfate | NAD+ | Substance P | Protoporphyrin IX | L-Glutathione reduced | L-Epinephrine | β-Nicotinamide mononucleotide | AZD9496 | L-DOPA | Adenosine

以上信息由企业自行提供，信息内容的真实性、准确性和合法性由相关企业负责，91化工仪器网对此不承担任何保证责任。
温馨提示：为规避购买风险，建议您在购买产品前务必确认供应商资质及产品质量。 搜本商铺 或 搜全站

MedChemExpress LLC - 主营产品： 西罗莫司 Rapamycin,瑞沙托维 TAK-242,奥拉帕尼 Olaparib

地址：上海市浦东新区张衡路1999弄3号楼      联系电话：86-021-58955995      手机：18019480960     传真：86-021-53700325
91化工仪器网 设计制作，未经允许翻录必究 .      Copyright(C) http://www.chem17.com,      All rights reserved. 以上信息由企业自行提供，信息内容的真实性、准确性和合法性由相关企业负责，91化工仪器网对此不承担任何保证责任。
温馨提示：为规避购买风险，建议您在购买产品前务必确认供应商资质及产品质量。
会员登录