lf-3 LF3-91化工仪器网

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更新时间：2019-06-25

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产品活性：LF3是β-Catenin/TCF4相互作用的拮抗剂，具有抗肿瘤活性。IC50值为1.65 μM。

研究领域：Stem Cell/Wnt

作用靶点：β-catenin

In Vitro: LF3 inhibits Wnt/β-catenin signals in cells with exogenous reporters and in colon cancer cells with endogenously high Wnt activity. LF3 also suppresses features of cancer cells related to Wnt signaling, including high cell motility, cell-cycle progression, and the overexpression of Wnt target genes. However, LF3 does not cause cell death or interfere with cadherin-mediated cell-cell adhesion. Remarkably, the self-renewal capacity of cancer stem cells is blocked by LF3 in concentration-dependent manners.

In Vivo: LF3 reduces tumor growth and induces differentiation in a mouse xenograft model of colon cancer. Tumor growth is significantly reduced when mice with GFPhigh cells are treated with LF3 at 50 mg/kg. LF3 treatment does not disturb the normal histology of the gut of mice.

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